Similar to many other medical cases, multiple sclerosis’ mechanism stays a mystery—an enigma made of complex environmental and genetic factors. A major piece to this enigma is the immune system, which is also accountable for managing many other pathological and physiological phenomena, comprising allergies. Even though earlier studies examining the relation between allergies and MS have given mixed outcomes, a research group at Brigham and Women’s Hospital wanted to uncover the supposed connection in a new manner. Examining the connection between inflammatory disease activity and allergy, the group discovered new proof linking relapses of multiple sclerosis and food allergies. The outcomes are posted in the Journal of Neurology, Neurosurgery & Psychiatry.
“Some MS patients with major allergies might complain of recurrent relapses related with their allergic incidents,” claimed neurologist at the Brigham at the Partners MS Center and senior author, Tanuja Chitnis, to the media in an interview. “We thought that the most probable mechanism related with allergy and its affect on MS might be associated to inflammatory activity.”
On a related note, multiple sclerosis is an autoimmune disorder in which the person’s own immune system damages and attacks the protective layering surrounding the nerve cells. A new results made by the research team of Roland Martin and Mireia Sospedra from the Clinical Research Priority Program Multiple Sclerosis of University of Zurich now recommend that it is worth expanding the research viewpoint to attain a better understanding of the pathological procedures.
In the Science Translational Medicine journal, the researchers claimed that T cells (the immune cells accountable for pathological procedures) react to a protein dubbed as GDP-L-fucose synthase. “We think that the immune cells are triggered in the intestine and then travel to the brain, where they create an inflammatory cascade when they interact with the human version of their target antigen,” claims Mireia Sospedra.